Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis.
Identifieur interne : 000417 ( Main/Exploration ); précédent : 000416; suivant : 000418Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis.
Auteurs : Benjamin Lacas [France] ; Jean Bourhis [Suisse] ; Jens Overgaard [Danemark] ; Qiang Zhang [États-Unis] ; Vincent Grégoire [Belgique] ; Matthew Nankivell [Royaume-Uni] ; Björn Zackrisson [Suède] ; Zbigniew Szutkowski [Pologne] ; Rafał Suwi Ski [Pologne] ; Michael Poulsen [Australie] ; Brian O'Sullivan [Canada] ; Renzo Corv [Italie] ; Sarbani Ghosh Laskar [Inde] ; Carlo Fallai [Italie] ; Hideya Yamazaki [Japon] ; Werner Dobrowsky [Royaume-Uni] ; Kwan Ho Cho [Corée du Sud] ; Adam S. Garden [États-Unis] ; Johannes A. Langendijk [Pays-Bas] ; Celia Maria Pais Viegas [Brésil] ; John Hay [Canada] ; Mohamed Lotayef [Égypte] ; Mahesh K B. Parmar [Royaume-Uni] ; Anne Aupérin [France] ; Carla Van Herpen [Pays-Bas] ; Philippe Maingon [France] ; Andy M. Trotti [États-Unis] ; Cai Grau [Danemark] ; Jean-Pierre Pignon [France] ; Pierre Blanchard [France]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2017.
Descripteurs français
- KwdFr :
- Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (mortalité), Carcinome épidermoïde (radiothérapie), Fractionnement de la dose d'irradiation, Humains, Tumeurs de la tête et du cou (anatomopathologie), Tumeurs de la tête et du cou (mortalité), Tumeurs de la tête et du cou (radiothérapie).
- MESH :
- anatomopathologie : Carcinome épidermoïde, Tumeurs de la tête et du cou.
- mortalité : Carcinome épidermoïde, Tumeurs de la tête et du cou.
- radiothérapie : Carcinome épidermoïde, Tumeurs de la tête et du cou.
- Fractionnement de la dose d'irradiation, Humains.
English descriptors
- KwdEn :
- MESH :
- mortality : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- pathology : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- radiotherapy : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- Dose Fractionation, Humans.
Abstract
The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials.
DOI: 10.1016/S1470-2045(17)30458-8
PubMed: 28757375
Affiliations:
- Australie, Belgique, Brésil, Canada, Corée du Sud, Danemark, France, Inde, Italie, Japon, Pays-Bas, Pologne, Royaume-Uni, Suisse, Suède, Égypte, États-Unis
- Angleterre, Canton de Vaud, Floride, Grand Londres, Groningue (province), Gueldre, Lombardie, Ontario, Pennsylvanie, Région de Bruxelles-Capitale, Texas, État de Rio de Janeiro, Île-de-France
- Bruxelles, Groningue, Lausanne, Londres, Milan, Nimègue, Orsay, Paris, Rio de Janeiro, Toronto
- University College de Londres, Université Paris-Sud, Université de Toronto
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Le document en format XML
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Langendijk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Viegas, Celia Maria Pais" sort="Viegas, Celia Maria Pais" uniqKey="Viegas C" first="Celia Maria Pais" last="Viegas">Celia Maria Pais Viegas</name><affiliation wicri:level="3"><nlm:affiliation>Radiation Oncology Department, Instituto Nacional de Cancer, Brasil National Cancer Institute, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Radiation Oncology Department, Instituto Nacional de Cancer, Brasil National Cancer Institute, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Hay, John" sort="Hay, John" uniqKey="Hay J" first="John" last="Hay">John Hay</name><affiliation wicri:level="1"><nlm:affiliation>Division of Radiation Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Radiation Oncology, British Columbia Cancer Agency, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Lotayef, Mohamed" sort="Lotayef, Mohamed" uniqKey="Lotayef M" first="Mohamed" last="Lotayef">Mohamed Lotayef</name><affiliation wicri:level="1"><nlm:affiliation>Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo</wicri:regionArea><wicri:noRegion>Cairo</wicri:noRegion></affiliation></author><author><name sortKey="Parmar, Mahesh K B" sort="Parmar, Mahesh K B" uniqKey="Parmar M" first="Mahesh K B" last="Parmar">Mahesh K B. 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Trotti</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Department of Radiation Oncology, Tampa, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Department of Radiation Oncology, Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Grau, Cai" sort="Grau, Cai" uniqKey="Grau C" first="Cai" last="Grau">Cai Grau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Clinical Oncology, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Experimental Clinical Oncology, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Pignon, Jean Pierre" sort="Pignon, Jean Pierre" uniqKey="Pignon J" first="Jean-Pierre" last="Pignon">Jean-Pierre Pignon</name><affiliation wicri:level="4"><nlm:affiliation>Ligue Nationale Contre le Cancer Meta-Analysis Platform, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France. 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xml:lang="fr">France</country><wicri:regionArea>Department of Radiation Therapy, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28757375</idno><idno type="pmid">28757375</idno><idno type="doi">10.1016/S1470-2045(17)30458-8</idno><idno type="wicri:Area/PubMed/Corpus">000528</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000528</idno><idno type="wicri:Area/PubMed/Curation">000526</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000526</idno><idno 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Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Ligue Nationale Contre le Cancer Meta-Analysis Platform, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bourhis, Jean" sort="Bourhis, Jean" uniqKey="Bourhis J" first="Jean" last="Bourhis">Jean Bourhis</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre Hospitalier Universitaire Vaudois, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Overgaard, Jens" sort="Overgaard, Jens" uniqKey="Overgaard J" first="Jens" last="Overgaard">Jens Overgaard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Clinical Oncology, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Experimental Clinical Oncology, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name><affiliation wicri:level="2"><nlm:affiliation>NRG Oncology Statistics and Data Management Center (formerly RTOG), Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>NRG Oncology Statistics and Data Management Center (formerly RTOG), Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Gregoire, Vincent" sort="Gregoire, Vincent" uniqKey="Gregoire V" first="Vincent" last="Grégoire">Vincent Grégoire</name><affiliation wicri:level="3"><nlm:affiliation>Radiation Oncology Department, UCL-Cliniques Universitaires St-Luc, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Radiation Oncology Department, UCL-Cliniques Universitaires St-Luc, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Nankivell, Matthew" sort="Nankivell, Matthew" uniqKey="Nankivell M" first="Matthew" last="Nankivell">Matthew Nankivell</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Zackrisson, Bjorn" sort="Zackrisson, Bjorn" uniqKey="Zackrisson B" first="Björn" last="Zackrisson">Björn Zackrisson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Radiation Sciences, Oncology, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Szutkowski, Zbigniew" sort="Szutkowski, Zbigniew" uniqKey="Szutkowski Z" first="Zbigniew" last="Szutkowski">Zbigniew Szutkowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiotherapy, Cancer Center, Marie Curie-Sklodowska Memorial Institute, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Radiotherapy, Cancer Center, Marie Curie-Sklodowska Memorial Institute, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Suwi Ski, Rafal" sort="Suwi Ski, Rafal" uniqKey="Suwi Ski R" first="Rafał" last="Suwi Ski">Rafał Suwi Ski</name><affiliation wicri:level="1"><nlm:affiliation>Radiotherapy and Chemotherapy Clinic and Teaching Hospital, Marie Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Radiotherapy and Chemotherapy Clinic and Teaching Hospital, Marie Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice</wicri:regionArea><wicri:noRegion>Gliwice</wicri:noRegion></affiliation></author><author><name sortKey="Poulsen, Michael" sort="Poulsen, Michael" uniqKey="Poulsen M" first="Michael" last="Poulsen">Michael Poulsen</name><affiliation wicri:level="1"><nlm:affiliation>Radiation Oncology Services, Mater Centre, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Radiation Oncology Services, Mater Centre, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="O Sullivan, Brian" sort="O Sullivan, Brian" uniqKey="O Sullivan B" first="Brian" last="O'Sullivan">Brian O'Sullivan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Corv, Renzo" sort="Corv, Renzo" uniqKey="Corv R" first="Renzo" last="Corv">Renzo Corv</name><affiliation wicri:level="1"><nlm:affiliation>IRCCS San Martino-IST, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS San Martino-IST, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Laskar, Sarbani Ghosh" sort="Laskar, Sarbani Ghosh" uniqKey="Laskar S" first="Sarbani Ghosh" last="Laskar">Sarbani Ghosh Laskar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Radiation Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Fallai, Carlo" sort="Fallai, Carlo" uniqKey="Fallai C" first="Carlo" last="Fallai">Carlo Fallai</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Yamazaki, Hideya" sort="Yamazaki, Hideya" uniqKey="Yamazaki H" first="Hideya" last="Yamazaki">Hideya Yamazaki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Dobrowsky, Werner" sort="Dobrowsky, Werner" uniqKey="Dobrowsky W" first="Werner" last="Dobrowsky">Werner Dobrowsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Freeman Hospital, Newcastle, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Freeman Hospital, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Kwan Ho" sort="Cho, Kwan Ho" uniqKey="Cho K" first="Kwan Ho" last="Cho">Kwan Ho Cho</name><affiliation wicri:level="1"><nlm:affiliation>Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang</wicri:regionArea><wicri:noRegion>Goyang</wicri:noRegion></affiliation></author><author><name sortKey="Garden, Adam S" sort="Garden, Adam S" uniqKey="Garden A" first="Adam S" last="Garden">Adam S. Garden</name><affiliation wicri:level="2"><nlm:affiliation>Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Langendijk, Johannes A" sort="Langendijk, Johannes A" uniqKey="Langendijk J" first="Johannes A" last="Langendijk">Johannes A. Langendijk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Viegas, Celia Maria Pais" sort="Viegas, Celia Maria Pais" uniqKey="Viegas C" first="Celia Maria Pais" last="Viegas">Celia Maria Pais Viegas</name><affiliation wicri:level="3"><nlm:affiliation>Radiation Oncology Department, Instituto Nacional de Cancer, Brasil National Cancer Institute, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Radiation Oncology Department, Instituto Nacional de Cancer, Brasil National Cancer Institute, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Hay, John" sort="Hay, John" uniqKey="Hay J" first="John" last="Hay">John Hay</name><affiliation wicri:level="1"><nlm:affiliation>Division of Radiation Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Radiation Oncology, British Columbia Cancer Agency, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Lotayef, Mohamed" sort="Lotayef, Mohamed" uniqKey="Lotayef M" first="Mohamed" last="Lotayef">Mohamed Lotayef</name><affiliation wicri:level="1"><nlm:affiliation>Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo</wicri:regionArea><wicri:noRegion>Cairo</wicri:noRegion></affiliation></author><author><name sortKey="Parmar, Mahesh K B" sort="Parmar, Mahesh K B" uniqKey="Parmar M" first="Mahesh K B" last="Parmar">Mahesh K B. Parmar</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Auperin, Anne" sort="Auperin, Anne" uniqKey="Auperin A" first="Anne" last="Aupérin">Anne Aupérin</name><affiliation wicri:level="4"><nlm:affiliation>Ligue Nationale Contre le Cancer Meta-Analysis Platform, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Ligue Nationale Contre le Cancer Meta-Analysis Platform, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Van Herpen, Carla" sort="Van Herpen, Carla" uniqKey="Van Herpen C" first="Carla" last="Van Herpen">Carla Van Herpen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Maingon, Philippe" sort="Maingon, Philippe" uniqKey="Maingon P" first="Philippe" last="Maingon">Philippe Maingon</name><affiliation wicri:level="3"><nlm:affiliation>European Organisation for Research and Treatment of Cancer, Radiation Oncology Group, Brussels, Belgium; Service d'Oncologie, Radiothérapie, Hôpitaux Universitaires Pitié Salpêtrière, Charles Foix, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>European Organisation for Research and Treatment of Cancer, Radiation Oncology Group, Brussels, Belgium; Service d'Oncologie, Radiothérapie, Hôpitaux Universitaires Pitié Salpêtrière, Charles Foix, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Trotti, Andy M" sort="Trotti, Andy M" uniqKey="Trotti A" first="Andy M" last="Trotti">Andy M. Trotti</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Department of Radiation Oncology, Tampa, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Department of Radiation Oncology, Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Grau, Cai" sort="Grau, Cai" uniqKey="Grau C" first="Cai" last="Grau">Cai Grau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Clinical Oncology, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Experimental Clinical Oncology, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Pignon, Jean Pierre" sort="Pignon, Jean Pierre" uniqKey="Pignon J" first="Jean-Pierre" last="Pignon">Jean-Pierre Pignon</name><affiliation wicri:level="4"><nlm:affiliation>Ligue Nationale Contre le Cancer Meta-Analysis Platform, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France. Electronic address: jean-pierre.pignon@gustaveroussy.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Ligue Nationale Contre le Cancer Meta-Analysis Platform, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Blanchard, Pierre" sort="Blanchard, Pierre" uniqKey="Blanchard P" first="Pierre" last="Blanchard">Pierre Blanchard</name><affiliation wicri:level="4"><nlm:affiliation>Department of Radiation Therapy, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Radiation Therapy, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carcinoma, Squamous Cell (mortality)</term><term>Carcinoma, Squamous Cell (pathology)</term><term>Carcinoma, Squamous Cell (radiotherapy)</term><term>Dose Fractionation</term><term>Head and Neck Neoplasms (mortality)</term><term>Head and Neck Neoplasms (pathology)</term><term>Head and Neck Neoplasms (radiotherapy)</term><term>Humans</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Carcinome épidermoïde (anatomopathologie)</term><term>Carcinome épidermoïde (mortalité)</term><term>Carcinome épidermoïde (radiothérapie)</term><term>Fractionnement de la dose d'irradiation</term><term>Humains</term><term>Tumeurs de la tête et du cou (anatomopathologie)</term><term>Tumeurs de la tête et du cou (mortalité)</term><term>Tumeurs de la tête et du cou (radiothérapie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de la tête et du cou</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dose Fractionation</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Fractionnement de la dose d'irradiation</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Brésil</li><li>Canada</li><li>Corée du Sud</li><li>Danemark</li><li>France</li><li>Inde</li><li>Italie</li><li>Japon</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>Égypte</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Canton de Vaud</li><li>Floride</li><li>Grand Londres</li><li>Groningue (province)</li><li>Gueldre</li><li>Lombardie</li><li>Ontario</li><li>Pennsylvanie</li><li>Région de Bruxelles-Capitale</li><li>Texas</li><li>État de Rio de Janeiro</li><li>Île-de-France</li></region><settlement><li>Bruxelles</li><li>Groningue</li><li>Lausanne</li><li>Londres</li><li>Milan</li><li>Nimègue</li><li>Orsay</li><li>Paris</li><li>Rio de Janeiro</li><li>Toronto</li></settlement><orgName><li>University College de Londres</li><li>Université Paris-Sud</li><li>Université de Toronto</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Lacas, Benjamin" sort="Lacas, Benjamin" uniqKey="Lacas B" first="Benjamin" last="Lacas">Benjamin Lacas</name></region><name sortKey="Auperin, Anne" sort="Auperin, Anne" uniqKey="Auperin A" first="Anne" last="Aupérin">Anne Aupérin</name><name sortKey="Blanchard, Pierre" sort="Blanchard, Pierre" uniqKey="Blanchard P" first="Pierre" last="Blanchard">Pierre Blanchard</name><name sortKey="Maingon, Philippe" sort="Maingon, Philippe" uniqKey="Maingon P" first="Philippe" last="Maingon">Philippe Maingon</name><name sortKey="Pignon, Jean Pierre" sort="Pignon, Jean Pierre" uniqKey="Pignon J" first="Jean-Pierre" last="Pignon">Jean-Pierre Pignon</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Bourhis, Jean" sort="Bourhis, Jean" uniqKey="Bourhis J" first="Jean" last="Bourhis">Jean Bourhis</name></region></country><country name="Danemark"><noRegion><name sortKey="Overgaard, Jens" sort="Overgaard, Jens" uniqKey="Overgaard J" first="Jens" last="Overgaard">Jens Overgaard</name></noRegion><name sortKey="Grau, Cai" sort="Grau, Cai" uniqKey="Grau C" first="Cai" last="Grau">Cai Grau</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name></region><name sortKey="Garden, Adam S" sort="Garden, Adam S" uniqKey="Garden A" first="Adam S" last="Garden">Adam S. Garden</name><name sortKey="Trotti, Andy M" sort="Trotti, Andy M" uniqKey="Trotti A" first="Andy M" last="Trotti">Andy M. Trotti</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Gregoire, Vincent" sort="Gregoire, Vincent" uniqKey="Gregoire V" first="Vincent" last="Grégoire">Vincent Grégoire</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Nankivell, Matthew" sort="Nankivell, Matthew" uniqKey="Nankivell M" first="Matthew" last="Nankivell">Matthew Nankivell</name></region><name sortKey="Dobrowsky, Werner" sort="Dobrowsky, Werner" uniqKey="Dobrowsky W" first="Werner" last="Dobrowsky">Werner Dobrowsky</name><name sortKey="Parmar, Mahesh K B" sort="Parmar, Mahesh K B" uniqKey="Parmar M" first="Mahesh K B" last="Parmar">Mahesh K B. Parmar</name></country><country name="Suède"><noRegion><name sortKey="Zackrisson, Bjorn" sort="Zackrisson, Bjorn" uniqKey="Zackrisson B" first="Björn" last="Zackrisson">Björn Zackrisson</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Szutkowski, Zbigniew" sort="Szutkowski, Zbigniew" uniqKey="Szutkowski Z" first="Zbigniew" last="Szutkowski">Zbigniew Szutkowski</name></noRegion><name sortKey="Suwi Ski, Rafal" sort="Suwi Ski, Rafal" uniqKey="Suwi Ski R" first="Rafał" last="Suwi Ski">Rafał Suwi Ski</name></country><country name="Australie"><noRegion><name sortKey="Poulsen, Michael" sort="Poulsen, Michael" uniqKey="Poulsen M" first="Michael" last="Poulsen">Michael Poulsen</name></noRegion></country><country name="Canada"><region name="Ontario"><name sortKey="O Sullivan, Brian" sort="O Sullivan, Brian" uniqKey="O Sullivan B" first="Brian" last="O'Sullivan">Brian O'Sullivan</name></region><name sortKey="Hay, John" sort="Hay, John" uniqKey="Hay J" first="John" last="Hay">John Hay</name></country><country name="Italie"><noRegion><name sortKey="Corv, Renzo" sort="Corv, Renzo" uniqKey="Corv R" first="Renzo" last="Corv">Renzo Corv</name></noRegion><name sortKey="Fallai, Carlo" sort="Fallai, Carlo" uniqKey="Fallai C" first="Carlo" last="Fallai">Carlo Fallai</name></country><country name="Inde"><noRegion><name sortKey="Laskar, Sarbani Ghosh" sort="Laskar, Sarbani Ghosh" uniqKey="Laskar S" first="Sarbani Ghosh" last="Laskar">Sarbani Ghosh Laskar</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Yamazaki, Hideya" sort="Yamazaki, Hideya" uniqKey="Yamazaki H" first="Hideya" last="Yamazaki">Hideya Yamazaki</name></noRegion></country><country name="Corée du Sud"><noRegion><name sortKey="Cho, Kwan Ho" sort="Cho, Kwan Ho" uniqKey="Cho K" first="Kwan Ho" last="Cho">Kwan Ho Cho</name></noRegion></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Langendijk, Johannes A" sort="Langendijk, Johannes A" uniqKey="Langendijk J" first="Johannes A" last="Langendijk">Johannes A. Langendijk</name></region><name sortKey="Van Herpen, Carla" sort="Van Herpen, Carla" uniqKey="Van Herpen C" first="Carla" last="Van Herpen">Carla Van Herpen</name></country><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Viegas, Celia Maria Pais" sort="Viegas, Celia Maria Pais" uniqKey="Viegas C" first="Celia Maria Pais" last="Viegas">Celia Maria Pais Viegas</name></region></country><country name="Égypte"><noRegion><name sortKey="Lotayef, Mohamed" sort="Lotayef, Mohamed" uniqKey="Lotayef M" first="Mohamed" last="Lotayef">Mohamed Lotayef</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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